PRS (Polygenic Risk Scores)
Polygenic Risk Scores (PRS) measure the component of illness risk resulting from numerous genetic variants dispersed throughout the genome. By comparing an individual’s PRS to a reference population of the same ancestry, the lifetime risk of disease can be computed.
Introduction
Traditional risk assessments primarily focus on uncommon abnormalities in specific genes, such as BRCA1/BRCA2 for breast cancer. However, with the development of large datasets and years of medical study, Polygenic Risk Scores now play a crucial role in determining disease etiology in the absence of other risk factors and evaluating an individual’s genetic risk of common diseases.
Age of Screening
PRS offers valuable information through screening age guidelines. For example, the risk of breast cancer increases with age for all women. The individual being tested is represented by the orange line on the chart, while a woman with an average PRS is represented by the blue line. The screening threshold (red line) indicates the 10-year risk that an average woman reaches at age 50, when mammography typically begins.
What We Test
- Alzheimer’s Disease (AD)
- Atrial Fibrillation (AF)
- Breast Cancer (BC)
- Coronary Artery Disease (CAD)
- Celiac Disease (CD)
- Colon Cancer (CRC)
- Hypo-HDL-Cholesterolemia (HDL)
- Hypertension (HT)
- Inflammatory Bowel Disease (IBD)
- Polygenic Hypercholesterolemia (LDL Cholesterol) (LDL)
- Lipoprotein(a) (LPA)
- Prostate Cancer (PC)
- Type 1 Diabetes (T1D)
- Type 2 Diabetes (T2D)
- Triglycerides (TG)
For comprehensive genetic risk assessment and personalized screening guidelines, our PRS tests offer valuable insights into disease predisposition.